Pan-Mass Challenge 2025 Rallies 6,500 Cyclists to Power Breakthrough Cancer Research

More than 6,500 cyclists and 3,500 volunteers are taking to Massachusetts roads this weekend as the Pan-Mass Challenge (PMC) returns for its 46th edition. With a bold target of $76 million, the world’s most successful athletic fundraiser continues its legacy of championing cancer research and treatment at Dana-Farber Cancer Institute.

Legacy of Impact

Founded in 1980, the PMC has raised $1.047 billion to date. Every dollar raised by riders goes directly to Dana-Farber, funding groundbreaking research and clinical advancements. Last year, the challenge hit a record $75 million, setting a high bar for 2025.

2025 Ride Highlights

Spanning 14 routes across Massachusetts, PMC 2025 covers up to 186 miles. Participants ride in honor of loved ones, with more than 1,100 riders identifying as cancer survivors or current patients—members of the PMC Living Proof® community.

Funding the Future of Oncology

The PMC directly supports Dana-Farber physicians who both participate and benefit from the event. Dr. Toni Choueiri, a veteran rider, is advancing a promising kidney cancer vaccine, while Dr. Allison O’Neill is preparing a pediatric immunotherapy trial, both powered by PMC funding.

Community and Commitment

“For 46 years, the PMC has been defined by grit, generosity, and a relentless commitment to funding cancer breakthroughs,” said Billy Starr, founder and chairman of the PMC and a Dana-Farber trustee. “We crossed the $1 billion threshold last year – and now we’re focused on what’s next. With the continued support of our riders, volunteers, donors and sponsors, I know this community will lead us toward our next billion and the next generation of progress.”

“As a 7-year rider, I’ve seen firsthand the passion, purpose, and power that fuel the PMC,” said Benjamin L. Ebert, MD, PhD, president and CEO of Dana-Farber. “The funds raised by this special community allow our researchers and clinicians to invest in research that is opening new frontiers in cancer treatment. I’m honored to ride alongside so many who are determined to make a difference, and I’m excited to see what we’ll accomplish together on the road to the next billion.”

Institutional Partnerships

Co-presented by the Red Sox Foundation® and M&T Bank, the PMC is Dana-Farber’s largest donor, contributing 66% of the Jimmy Fund’s annual revenue. The PMC model is globally recognized for its unmatched fundraising efficiency and community engagement.

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